The development of an adaptive response of <i>Drosophila melanogaster</i> to genotoxicity of alkyl(aryl)sulfurnyl 1,2,4-triazoles

The widespread use of triazoles in agriculture as retardants has led to the need investigate possible mutagenic effects these compounds on natural ecosystems adjacent agrocoenoses. Model experiments were set up ability induce dominant lethal mutations by synthesized triazoles: 1,2,4-triazole: (1,2,4-triazole (1,2,4-TrH), N-triazolid methanesulfonic acid (CH₃SO₂TrH), benzene sulfonic (PhSO₂1,2,4-Tr) and toluene (4-CH₃ ArSO₂1,2,4-Tr) Drosophila melanogaster adults. possibility developing an adaptive response was studied. A relationship between structure physicochemical properties studied alkyl(aryl)sulfonyl 1,2,4-triazoles their mutagenicity analyzed. series constructed which for adults decreases following order: CH₃SO₂TrH 1,2,4-TrH PhSO₂1,2,4-TrH 4-CH₃ArSO₂1,2,4-TrH, both when exposed non-toxic doses substances (0,001 mg/ml concentration) at a dose LD₅₀. It been established that short-term (within day) preliminary action nontoxic (0,0001 mg/ml) followed same LD₅₀ causes only females melanogaster. Long-term exposure (the entire larval life period drosophila) then repeated caused significant decrease number induced lethalities well drosophila males. Consequently, developed tissues with active cell division. is supposed repair mechanisms leading development larvae are different.